A robust brain signature region approach for episodic memory performance in older adults.

ABSTRACT: The brain signature concept aims to characterize brain regions most strongly associated with an outcome of interest. Brain signatures derive their power from data-driven searches that select features based solely on performance metrics of prediction or classification. This approach has important potential to delineate biologically relevant brain substrates for prediction or classification of future trajectories. Recent work has used exploratory voxel-wise or atlas-based searches, with some using machine learning techniques to define salient features. These have shown undoubted usefulness, but two issues remain. The preponderance of recent work has been aimed at categorical rather than continuous outcomes, and it is rare for non-atlas reliant voxel-based signatures to be reported that would

SUBMITTER: Fletcher E 

PROVIDER: S-EPMC8105039 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature