Helix-Loop-Helix Factor Id3 (Inhibitor of Differentiation 3): A Novel Regulator of Hyaluronan-Mediated Adipose Tissue Inflammation.

ABSTRACT:

Objective

The aim of this study was to unravel mechanisms whereby deficiency of the transcription factor Id3 (inhibitor of differentiation 3) leads to metabolic dysfunction in visceral obesity. We investigated the impact of loss of Id3 on hyaluronic acid (HA) production by the 3 HAS isoenzymes (HA synthases; -1, -2, and -3) and on obesity-induced adipose tissue (AT) accumulation of proinflammatory B cells. Approach and Results: Male Id3^-/- mice and respective wild-type littermate controls were fed a 60% high-fat diet for 4 weeks. An increase in inflammatory B2 cells was detected in Id3^-/- epididymal AT. HA accumulated in epididymal AT of high-fat diet-fed Id3^-/- mice and circulating levels of HA were elevated. Has2 mRNA e

SUBMITTER: Misiou A 

PROVIDER: S-EPMC8105274 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature