Biomolecular Modeling and Simulation: A Prospering Multidisciplinary Field.

ABSTRACT: We reassess progress in the field of biomolecular modeling and simulation, following up on our perspective published in 2011. By reviewing metrics for the field's productivity and providing examples of success, we underscore the productive phase of the field, whose short-term expectations were overestimated and long-term effects underestimated. Such successes include prediction of structures and mechanisms; generation of new insights into biomolecular activity; and thriving collaborations between modeling and experimentation, including experiments driven by modeling. We also discuss the impact of field exercises and web games on the field's progress. Overall, we note tremendous success by the biomolecular modeling community in utilization of computer power; improvement in force fields; and

SUBMITTER: Schlick T 

PROVIDER: S-EPMC8105287 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature