Ontology highlight
ABSTRACT:
SUBMITTER: Avin KG
PROVIDER: S-EPMC8105324 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Avin Keith G KG Hughes Meghan C MC Chen Neal X NX Srinivasan Shruthi S O'Neill Kalisha D KD Evan Andrew P AP Bacallao Robert L RL Schulte Michael L ML Moorthi Ranjani N RN Gisch Debora L DL Perry Christopher G R CGR Moe Sharon M SM O'Connell Thomas M TM
Scientific reports 20210507 1
Chronic kidney disease (CKD) leads to musculoskeletal impairments that are impacted by muscle metabolism. We tested the hypothesis that 10-weeks of voluntary wheel running can improve skeletal muscle mitochondria activity and function in a rat model of CKD. Groups included (n = 12-14/group): (1) normal littermates (NL); (2) CKD, and; (3) CKD-10 weeks of voluntary wheel running (CKD-W). At 35-weeks old the following assays were performed in the soleus and extensor digitorum longus (EDL): targeted ...[more]