Network pharmacology integrated with experimental validation revealed the anti-inflammatory effects of Andrographis paniculata.

ABSTRACT: Inflammation is a key factor in the development and complications of various diseases because it has a complex pathogenesis. Andrographis paniculate (Burm. f.) Nees (Chuan Xinlian) is a well-known form of Traditional Chinese Medicine (TCM) applied in clearing heat and detoxification. Also, it is rich in bioactive lactones, with various anti-inflammatory activities. Here, network pharmacology combined with molecular biology experimental approach was used to predict and verify the potential molecular mechanism of Chuan Xinlian in treating inflammation. The bioactive ingredients of Chuan Xinlian were obtained from the TCMSP database and literature. Besides, the targets of Chuan Xinlian and inflammation were collected based on the multi-source databases and used to generate the PPI network. Ne

SUBMITTER: Zhu N 

PROVIDER: S-EPMC8105393 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature