Repurposing of antidiabetics as Serratia marcescens virulence inhibitors.

ABSTRACT:

Background

Serratia marcescens becomes an apparent nosocomial pathogen and causes a variety of infections. S. marcescens possess various virulence factors that are regulated by intercellular communication system quorum sensing (QS). Targeting bacterial virulence is a proposed strategy to overcome bacterial resistance. Sitagliptin anti-QS activity has been demonstrated previously and we aimed in this study to investigate the effects of antidiabetic drugs vildagliptin and metformin compared to sitagliptin on S. marcescens pathogenesis.

Methods

We assessed the effects of tested drugs in subinhibitory concentrations phenotypically on the virulence factors and genotypically on the virulence encoding genes' expressions. The protection of tested drugs on S. marcescens pathogenesis

SUBMITTER: Hegazy WAH 

PROVIDER: S-EPMC8105466 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature