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Gut microbiota, determined by dietary nutrients, drive modification of the plasma lipid profile and insulin resistance.

ABSTRACT: The gut microbiota metabolizes the nutrients to produce various metabolites that play crucial roles in host metabolism. However, the links between the microbiota established by different nutrients and the microbiota-influenced changes in the plasma lipids remain unclear. Diets rich in cornstarch, fructose, branched chain amino acids, soybean oil (SO), or lard established a unique microbiota and had influence on glucose metabolism, which was partially reproduced by transferring the microbiota. Comparison of plasma lipidomic analysis between germ-free and colonized mice revealed significant impacts of the microbiota on various lipid classes, and of note, the microbiota established by the SO diet, which was associated with the greatest degree of glucose intolerance, caused the maximum alteration of the plasma lipid profile. Thus, the gut microbiota composed of dietary nutrients was associated with dynamic changes in the lipids potentially having differential effects on glucose metabolism.

SUBMITTER: Watanabe Y

PROVIDER: S-EPMC8105675 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

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Gut microbiota, determined by dietary nutrients, drive modification of the plasma lipid profile and insulin resistance.

Watanabe Yoshiyuki Y Fujisaka Shiho S Ikeda Kazutaka K Ishikawa Masaki M Yamada Takahiro T Nawaz Allah A Kado Tomonobu T Kuwano Takahide T Nishimura Ayumi A Bilal Muhammad M Liu Jianhui J Yagi Kunimasa K Hase Koji K Tobe Kazuyuki K

iScience 20210416 5

The gut microbiota metabolizes the nutrients to produce various metabolites that play crucial roles in host metabolism. However, the links between the microbiota established by different nutrients and the microbiota-influenced changes in the plasma lipids remain unclear. Diets rich in cornstarch, fructose, branched chain amino acids, soybean oil (SO), or lard established a unique microbiota and had influence on glucose metabolism, which was partially reproduced by transferring the microbiota. Co ...[more]

PMID: 33997711

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Dataset Information

Gut microbiota, determined by dietary nutrients, drive modification of the plasma lipid profile and insulin resistance.

Publications

Gut microbiota, determined by dietary nutrients, drive modification of the plasma lipid profile and insulin resistance.

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