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The evolving landscape of immunotherapy in solid tumors.

ABSTRACT: While surgical resection, local and cytotoxic therapies have long formed the basis of cancer care, immunotherapy now plays a key role in supplementing and even replacing these agents in the first line. Here we review the early success of programmed cell death protein 1 (PD-1) and cytotoxic T-lymphocyte associated protein 4 blockade and discuss biomarkers of therapeutic response. We next highlight a select group of novel targets in Phase III trials both as monotherapies and in combination with PD-1 inhibitors. Finally, we discuss innovations which seek to improve outcomes in therapy-resistant solid tumors.

SUBMITTER: Keilson JM

PROVIDER: S-EPMC8105678 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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The evolving landscape of immunotherapy in solid tumors.

Keilson Jessica M JM Knochelmann Hannah M HM Paulos Chrystal M CM Kudchadkar Ragini R RR Lowe Michael C MC

Journal of surgical oncology 20210301 3

While surgical resection, local and cytotoxic therapies have long formed the basis of cancer care, immunotherapy now plays a key role in supplementing and even replacing these agents in the first line. Here we review the early success of programmed cell death protein 1 (PD-1) and cytotoxic T-lymphocyte associated protein 4 blockade and discuss biomarkers of therapeutic response. We next highlight a select group of novel targets in Phase III trials both as monotherapies and in combination with PD ...[more]

PMID: 33595890

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