Ontology highlight
ABSTRACT:
SUBMITTER: Black KA
PROVIDER: S-EPMC8105722 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Black Katherine A KA Duan Lijun L Mandyoli Lungelo L Selbach Bruna P BP Xu Weizhen W Ehrt Sabine S Sacchettini James C JC Rhee Kyu Y KY
The Journal of experimental medicine 20210505 7
Comparative sequence analysis has enabled the annotation of millions of genes from organisms across the evolutionary tree. However, this approach has inherently biased the annotation of phylogenetically ubiquitous, rather than species-specific, functions. The ecologically unusual pathogen Mycobacterium tuberculosis (Mtb) has evolved in humans as its sole reservoir and emerged as the leading bacterial cause of death worldwide. However, the physiological factors that define Mtb's pathogenicity are ...[more]