Identification of four genes and biological characteristics associated with acute spinal cord injury in rats integrated bioinformatics analysis.

ABSTRACT:

Background

Spinal cord injury (SCI) is a serious condition that can cause physical disability and sensory dysfunction. Cytokines play an extremely important role in the acute phase of SCI. Clarifying the cytokine expression profile is of great importance.

Methods

Cytokine array analysis was used to explore the changes in 67 different proteins at 0 hours, 2 hours, 1 day, 3 days, and 7 days after acute SCI in rats. The differentially expressed cytokines in the various periods were analyzed and compared. The biological processes related to the differentially expressed proteins were examined using Gene Ontology (GO) analysis.

Results

Immediately after SCI (0 hours), only ciliary neurotrophic factor (CNTF) was slightly up-regulated, while 23 other proteins were down-regula

SUBMITTER: Li Q 

PROVIDER: S-EPMC8105796 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature