UAP1L1 plays an oncogene-like role in glioma through promoting proliferation and inhibiting apoptosis.

ABSTRACT:

Background

Uridine diphosphate-N-acetylglucosamine pyrophosphorylase-1-like-1 (UAP1L1) is involved in protein glycosylation and promotes proliferation in some tumors. By analyzing the publicly available Gene Expression Omnibus (GEO) database, we found that UAP1L1 displayed a significant change between paired glioma and normal brain tissues. The purpose of this study was to investigate the expression and functional role of UAP1L1 in glioma.

Methods

To determine the expression level of UAP1L1 in glioma, immunohistochemistry (IHC) staining was performed in tissue microarrays of 160 gliomas and 24 normal brain tissues. The correlation between UAP1L1 expression and the outcomes of glioma patients was analyzed. Human glioblastoma cell line

SUBMITTER: Yang Z 

PROVIDER: S-EPMC8105798 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature