Potential functional variants of KIAA genes are associated with breast cancer risk in a case control study.

ABSTRACT:

Background

KIAA genes identified in the Kazusa cDNA-sequencing project may play important roles in biological processes and are involved in carcinogenesis of many cancers. Genetic variants of KIAA genes are implicated in the abnormal expression of these genes and are linked to susceptibility of several human complex diseases.

Methods

The differentially expressed KIAA genes were screened and identified in The Cancer Genome Atlas (TCGA) database of breast cancer. A total of 48 variants located in the 28 KIAA genes were selected to investigate the associations between polymorphism and breast cancer in 1,032 cases and 1,063 cancer-free controls in a Chinese population.

Results

Two coding variants, which included a SNP rs2306369 in KIAA1109 and a SNP rs1205434 in

SUBMITTER: Zhou J 

PROVIDER: S-EPMC8105804 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature