CSF SERPINA3 Levels Are Elevated in Patients With Progressive MS.

ABSTRACT: To identify biomarkers associated with progressive phases of MS and with neuroprotective potential. Combined analysis of the transcriptional and proteomic profiles obtained in CNS tissue during chronic progressive phases of experimental autoimmune encephalomyelitis (EAE) with the transcriptional profile obtained during the differentiation of murine neural stem cells into neurons. Candidate biomarkers were measured by ELISA in the CSF of 65 patients with MS (29 with relapsing-remitting MS [RRMS], 20 with secondary progressive MS, and 16 with primary progressive MS [PPMS]) and 30 noninflammatory neurologic controls (NINCs). Integrative analysis of gene and protein expression data identified 2 biomarkers, the serine protease inhibitor Serpina3n and the calcium-binding protein S100A4, which we

SUBMITTER: Fissolo N 

PROVIDER: S-EPMC8105904 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature