Structural and Clinical Correlates of a Periventricular Gradient of Neuroinflammation in Multiple Sclerosis.

ABSTRACT:

Objectives

To explore in vivo innate immune cell activation as a function of the distance from ventricular CSF in patients with multiple sclerosis (MS) using [¹⁸F]-DPA714 PET and to investigate its relationship with periventricular microstructural damage, evaluated by magnetization transfer ratio (MTR), and with trajectories of disability worsening.

Methods

Thirty-seven patients with MS and 19 healthy controls underwent MRI and [¹⁸F]-DPA714 TSPO dynamic PET, from which individual maps of voxels characterized by innate immune cell activation (DPA+) were generated. White matter (WM) was divided in 3-mm-thick concentric rings radiating from the ventricular surface toward the cortex, and the percentage of DPA+ voxels and mean MTR were extracted from each ri

SUBMITTER: Poirion E 

PROVIDER: S-EPMC8105971 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature