APOBEC3B deletion polymorphism and lung cancer risk in the southern Chinese population.

ABSTRACT:

Background

Approximately 80-85% of lung cancer is the non-small cell lung cancer (NSCLC) subtype, which ranks as the leading cause of cancer deaths worldwide. APOBEC3B (A3B) was reported to be a key source of mutations in NSCLC. However, the role of the A3B deletion polymorphism in the etiology of NSCLC has not been well-documented.

Methods

A case-control study with 317 NSCLC patients and 334 healthy controls was conducted to explore the association between the A3B deletion polymorphism and the risk of NSCLC. The unconditional logistic regression model was performed to calculate the odds ratio (OR) and the 95% confidence interval (CI), and the confounding factors were adjusted, including age, gender, and smoking status, to estimate the risk. An analysis of gene-enviro

SUBMITTER: Ben X 

PROVIDER: S-EPMC8105993 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature