Large HDL₂ combined with inflammatory factors as superior predictors for coronary artery disease than small HDL₃.

ABSTRACT:

Background

This study investigated whether combinations of high-density lipoprotein (HDL) subfractions and inflammatory markers would add value to coronary artery disease (CAD) prediction.

Methods

Non-CAD subjects (n=245) were stratified into low/moderate/high-Framingham risk (L/M/H-FR) groups and 180 CAD patients were enrolled. Levels of HDL-C, HDL₂, HDL₃, monocyte chemoattractant protein-1 (MCP-1), and high-sensitivity C-reactive protein (hsCRP) were measured. Multivariable logistic models for CAD were estimated with a single parameter or all parameters together after adjustment for conventional risk factors (CRFs), and Z statistics, net reclassification improvement (NRI), and integrated discrimination improvement (IDI) were used to compare discrimina

SUBMITTER: Wu X 

PROVIDER: S-EPMC8106016 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature