CD2⁺ T-helper 17-like cells differentiated from a CD133⁺ subpopulation of non-small cell lung carcinoma cells promote the growth of lung carcinoma.

ABSTRACT:

Background

Cancer stem cells (CSCs) give rise to a diverse variety of differentiated cells, which comprise the bulk of the tumor microenvironment (TME). However, the exact multi-directional differentiation potential of CSCs has not been fully clarified. This study was designed to explore whether CSCs differentiate into cellular components of the TME to promote the growth of lung carcinoma.

Methods

The present of CD133⁺, CD2⁺, and CD133⁺CD2⁺ cells in both clinical lung adenocarcinoma tissue and non-small cell lung carcinoma (NSCLC) cell lines were monitored using polymerase chain reaction (PCR) Array, flow cytometry (FCM), quantitative real-time PCR (qRT-PCR) and immunohistofluorescence (IF). Stem-like properties of CD133⁺

SUBMITTER: Jia M 

PROVIDER: S-EPMC8106049 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature