Mechanism of idiosyncratic drug induced liver injury (DILI): unresolved basic issues.

ABSTRACT: Clinical features of idiosyncratic drug induced liver injury (DILI) are well described in cases that have been assessed for causality using the Roussel Uclaf Causality Assessment Method (RUCAM), but our understanding of the mechanistic steps leading to injury is fragmentary. The difficulties describing mechanistic events can be traced back to the lack of an animal model of experimental idiosyncratic DILI that can mimic the genetic requirements of human idiosyncratic DILI. However, immune tolerance plays a dominant role in the immune response of the liver, and impairment of immune tolerance with immune checkpoint inhibitors increases DILI in both humans and animals. This may provide one method to study the individual steps involved. In general. the human DILI liver is a secret keeper provid

SUBMITTER: Teschke R 

PROVIDER: S-EPMC8106057 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature