Related parameters of affinity and stability prediction of HLA-A*2402 restricted antigen peptides based on molecular docking.

ABSTRACT:

Background

Major histocompatibility complex class I (MHC-I) plays an important role in cell immune response, and stable interaction between polypeptides and MHC-I ensures efficient presentation of polypeptide-MHC-I (pMHC-I) molecular complexes to T cells. The aim of this study was to explore ways to improve the affinity and stability of the p-Human Leukocyte Antigen (HLA)-A*2402 complex.

Methods

The peptide sequences of the restricted antigen peptides for HLA-A*2402 and the results of the in vitro competitive binding test were retrieved from the literature. The affinity values were predicted using NetMHCpan v4.1 server, and the stability values were predicted using the NetMHCstab v1.0 server. Auto Vina was used to dock peptides to HLA-A*2402 protein in a flexible dock

SUBMITTER: Huang C 

PROVIDER: S-EPMC8106073 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature