Protocatechualdehyde restores endothelial dysfunction in streptozotocin-induced diabetic rats.

ABSTRACT:

Background

The present study was conducted with the aim of clarifying the effects of protocatechualdehyde (PCA) on the endothelial function in streptozotocin (STZ)-induced diabetic rats.

Methods

Sprague Dawley (SD) rats were intraperitoneally injected with STZ (single dose of 60 mg/kg). Diabetic model rats were given PCA (25 mg/kg/day) via gavage feeding for 6 weeks. Vascular function was studied; superoxide anion and nitrotyrosine levels were assessed; and nicotinamide adenine dinucleotide phosphate hydrogen (NADPH) oxidase as well as total superoxide dismutase (SOD) activity were detected. Protein expression of phosphorylated endothelial nitric oxide synthase (P-eNOS), total endothelial nitric oxide synthase (T-eNOS), p22^phox, p47^phox and Cu/Zn-SOD we

SUBMITTER: Ji B 

PROVIDER: S-EPMC8106075 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature