Global alternative splicing landscape of skeletal muscle atrophy induced by hindlimb unloading.

ABSTRACT:

Background

Long-term exposure to microgravity will cause skeletal muscle atrophy, which can cause serious harm to astronauts in space travel. Therefore, it is important to explore skeletal muscle atrophy's molecular mechanism for its prevention and treatment. However, as an important regulatory approach of skeletal muscle physiology, the role of alternative splicing in skeletal muscle atrophy, especially skeletal muscle atrophy caused by disuse, is unclear.

Methods

We established a rat hindlimb unloading model and performed RNA sequencing on soleus muscle, which was seriously atrophied during unloading. Several bioinformatics methods were used to identify alternative splicing events and determine their gene functions.

Results

Many alternative splicing events were foun

SUBMITTER: Sun J 

PROVIDER: S-EPMC8106077 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature