Development and validation of a collagen signature-based nomogram for preoperatively predicting lymph node metastasis and prognosis in colorectal cancer.

ABSTRACT:

Background

Current preoperative evaluation approaches cannot provide adequate information for the prediction of lymph node (LN) metastasis in colorectal cancer (CRC). Collagen alterations in the tumor microenvironment affect the progression of tumor cells. To more accurately assess the LN status of CRC preoperatively, we developed and validated a collagen signature-based nomogram for predicting LN metastasis in CRC.

Methods

In total, 342 consecutive CRC patients were assigned to the training and validation cohorts. A total of 148 fully quantitative collagen features were extracted based on preoperative biopsies using multiphoton imaging, and the least absolute shrinkage and selection operator method was utilized to construct the collagen signature. A collagen signature-based

SUBMITTER: Fu M 

PROVIDER: S-EPMC8106085 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature