Dual RNAseq highlights the kinetics of skin microbiome and fish host responsiveness to bacterial infection.

ABSTRACT:

Background

Tenacibaculum maritimum is a fish pathogen known for causing serious damage to a broad range of wild and farmed marine fish populations worldwide. The recently sequenced genome of T. maritimum strain NCIMB 2154^T provided unprecedented information on the possible molecular mechanisms involved in the virulence of this species. However, little is known about the dynamic of infection in vivo, and information is lacking on both the intrinsic host response (gene expression) and its associated microbiota. Here, we applied complementary omic approaches, including dual RNAseq and 16S rRNA gene metabarcoding sequencing using Nanopore and short-read Illumina technologies to unravel the host-pathogen interplay in an experimental infection system using the tropical fish Pl

SUBMITTER: Le Luyer J 

PROVIDER: S-EPMC8106148 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature