Tributyltin perturbs femoral cortical architecture and polar moment of inertia in rat.

ABSTRACT:

Background

Tributyltin, a well-known endocrine disruptor, is widely used in agriculture and industry. Previous studies have shown that tributyltin could cause deleterious effects on bone health by impairing the adipo-osteogenic balance in bone marrow.

Methods

To investigate further the effects of tributyltin on bone, weaned male SD rats were treated with tributyltin (0.5, 5 or 50 μg·kg^- 1) or corn oil by gavage once every 3 days for 60 days in this study. Then, we analyzed the effects of tributyltin on geometry, the polar moment of inertia, mineral content, relative abundances of mRNA from representative genes related to adipogenesis and osteogenesis, serum calcium ion and inorganic phosphate levels.

Results

Micro-computed tomography analysis revealed that

SUBMITTER: Li M 

PROVIDER: S-EPMC8106170 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature