Sex differences in the association of prediabetes and type 2 diabetes with microvascular complications and function: The Maastricht Study.

ABSTRACT:

Background

Women with type 2 diabetes are disproportionally affected by macrovascular complications; we here investigated whether this is also the case for microvascular complications and retinal microvascular measures.

Methods

In a population-based cohort study of individuals aged 40-75 years (n = 3410; 49% women, 29% type 2 diabetes (oversampled by design)), we estimated sex-specific associations, and differences therein, of (pre)diabetes (reference: normal glucose metabolism), and of continuous measures of glycemia with microvascular complications and retinal measures (nephropathy, sensory neuropathy, and retinal arteriolar and venular diameters and dilatation). Sex differences were analyzed using regression models with interaction terms (i.e. sex-by- (pre)diabetes and se

SUBMITTER: de Ritter R 

PROVIDER: S-EPMC8106227 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature