High Frequency Spectral Ultrasound Imaging Detects Early Heterotopic Ossification in Rodents.

ABSTRACT: Heterotopic ossification (HO) is a devastating condition in which ectopic bone forms inappropriately in soft tissues following traumatic injuries and orthopedic surgeries as a result of aberrant mesenchymal progenitor cell (MPC) differentiation. HO leads to chronic pain, decreased range of motion, and an overall decrease in quality of life. While several treatments have shown promise in animal models, all must be given during early stages of formation. Methods for early determination of whether and where endochondral ossification/soft tissue mineralization (HO anlagen) develop are lacking. At-risk patients are not identified sufficiently early in the process of MPC differentiation and soft tissue endochondral ossification for potential treatments to be effective. Hence, a critical need exi

SUBMITTER: Edwards NJ 

PROVIDER: S-EPMC8106252 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature