Construction of an immune-related signature with prognostic value for colon cancer.

ABSTRACT:

Background

Colon cancer is the third most common malignant tumor in the world. Although immunotherapy has been used in cancer treatment, there is still no first-line immunotherapy method for colon cancer. Therefore, it is essential to search for potential immunotherapy targets and molecular biomarkers for early diagnosis and prognosis.

Methods

In this study, we downloaded transcriptome data from The Cancer Genome Atlas (TCGA) and immune-related genes from the ImmPort database. Then we filtered genes with prognostic value and constructed an immune-related signature. Patients were classified into low- and high-risk groups, and we exerted a series of analysis between the signature and clinical phenotypes. Additionally, we used protein-protein interaction networks, gene set enri

SUBMITTER: Lv Y 

PROVIDER: S-EPMC8106397 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature