Decreased availability of nitric oxide and hydrogen sulfide is a hallmark of COVID-19.

ABSTRACT:

Background

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is involved in a global outbreak affecting millions of people who manifest a variety of symptoms. Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 is increasingly associated with cardiovascular complications requiring hospitalizations; however, the mechanisms underlying these complications remain unknown. Nitric oxide (NO) and hydrogen sulfide (H₂S) are gasotransmitters that regulate key cardiovascular functions.

Methods

Blood samples were obtained from 68 COVID-19 patients and 33 controls and NO and H₂S metabolites were assessed. H₂S and NO levels were compared between cases and controls in the entire study population and subgroups based on race. The availability

SUBMITTER: Dominic P 

PROVIDER: S-EPMC8106525 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature