Circulating trimethylamine N-oxide in association with diet and cardiometabolic biomarkers: an international pooled analysis.

ABSTRACT:

Background

Trimethylamine N-oxide (TMAO), a diet-derived, gut microbial-host cometabolite, has been linked to cardiometabolic diseases. However, the relations remain unclear between diet, TMAO, and cardiometabolic health in general populations from different regions and ethnicities.

Objectives

To examine associations of circulating TMAO with dietary and cardiometabolic factors in a pooled analysis of 16 population-based studies from the United States, Europe, and Asia.

Methods

Included were 32,166 adults (16,269 white, 13,293 Asian, 1247 Hispanic/Latino, 1236 black, and 121 others) without cardiovascular disease, cancer, chronic kidney disease, or inflammatory bowel disease. Linear regression coefficients (β) were computed for standardized TMAO with harmonized variabl

SUBMITTER: Yang JJ 

PROVIDER: S-EPMC8106754 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature