FOXO1 expression in chondrocytes modulates cartilage production and removal in fracture healing.

ABSTRACT: Fracture healing is a multistage process characterized by inflammation, cartilage formation, bone deposition, and remodeling. Chondrocytes are important in producing cartilage that forms the initial anlagen for the hard callus needed to stabilize the fracture site. We examined the role of FOXO1 by selective ablation of FOXO1 in chondrocytes mediated by Col2α1 driven Cre recombinase. Experimental mice with lineage-specific FOXO1 deletion (Col2α1Cre⁺FOXO1^L/L) and negative control littermates (Col2α1Cre^-FOXO1^L/L) were used for in vivo, closed fracture studies. Unexpectedly, we found that in the early phases of fracture healing, FOXO1 deletion significantly increased the amount of cartilage formed, whereas, in later periods, FOXO1 deletion led to a g

SUBMITTER: Ding Z 

PROVIDER: S-EPMC8106874 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature