Dynamics of B cell repertoires and emergence of cross-reactive responses in patients with different severities of COVID-19.

ABSTRACT: Individuals with the 2019 coronavirus disease (COVID-19) show varying severity of the disease, ranging from asymptomatic to requiring intensive care. Although monoclonal antibodies specific to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been identified, we still lack an understanding of the overall landscape of B cell receptor (BCR) repertoires in individuals with COVID-19. We use high-throughput sequencing of bulk and plasma B cells collected at multiple time points during infection to characterize signatures of the B cell response to SARS-CoV-2 in 19 individuals. Using principled statistical approaches, we associate differential features of BCRs with different disease severity. We identify 38 significantly expanded clonal lineages shared among individuals as can

SUBMITTER: Montague Z 

PROVIDER: S-EPMC8106887 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature