Synaptic Effect of Aδ-Fibers by Pulse-Train Electrical Stimulation.

ABSTRACT: Electrical stimulation of specific small fibers (Aδ- and C-fibers) is used in basic studies on nociception and neuropathic pain and to diagnose neuropathies. For selective stimulation of small fibers, the optimal stimulation waveform parameters are an important aspect together with the study of electrode design. However, determining an optimal stimulation condition is challenging, as it requires the characterization of the response of the small fibers to electrical stimulation. The perception thresholds are generally characterized using single-pulse stimulation based on the strength-duration curve. However, this does not account for the temporal effects of the different waveforms used in practical applications. In this study, we designed an experiment to characterize the effects of multipl

SUBMITTER: Tanaka S 

PROVIDER: S-EPMC8107290 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature