Focal Loss Analysis of Nerve Fiber Layer Reflectance for Glaucoma Diagnosis.

ABSTRACT:

Purpose

To evaluate nerve fiber layer (NFL) reflectance for glaucoma diagnosis.

Methods

Participants were imaged with 4.5 × 4.5 mm volumetric disc scans using spectral-domain optical coherence tomography. The normalized NFL reflectance map was processed by an azimuthal filter to reduce directional reflectance bias caused by variation of beam incidence angle. The peripapillary area of the map was divided into 160 superpixels. Average reflectance was the mean of superpixel reflectance. Low-reflectance superpixels were identified as those with NFL reflectance below the fifth percentile normative cutoff. Focal reflectance loss was measured by summing loss in low-reflectance superpixels.

Results

Thirty-five normal, 30 preperimetric, and 35 perimetric glaucoma participants

SUBMITTER: Tan O 

PROVIDER: S-EPMC8107497 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature