Association between serum adipsin and plaque vulnerability determined by optical coherence tomography in patients with coronary artery disease.

ABSTRACT:

Background

Early identification of vulnerable plaques is important for patients with coronary artery disease (CAD) to reduce acute coronary events and improve their prognosis. We sought to examine the relationship between adipsin, an adipokine secreted from adipocytes, and plaque vulnerability in CAD patients.

Methods

A total of 103 plaques from 99 consecutive patients who underwent coronary angiography were assessed by optical coherence tomography. The serum level of adipsin was measured using enzyme-linked immunosorbent assay (ELISA). The accuracy of adipsin for detecting thin-cap fibroatheroma (TCFA) was determined by the area under the receiver operating characteristic curve (AUC).

Results

Of the 99 patients, 49 were classified into the low adipsin group and 50 in

SUBMITTER: Sun R 

PROVIDER: S-EPMC8107545 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature