The roles of the cell division cycle-associated gene family in hepatocellular carcinoma.

ABSTRACT:

Background

The members of the cell division cycle-associated (CDCA) gene family are significant regulators of cell proliferation known to play key roles in various cancers. However, the function of CDCA genes in hepatocellular carcinoma (HCC) is unclear. The aim of this research was to clarify the roles of CDCA family members in HCC using bioinformatics analysis tools.

Methods

We studied data on the mRNA and protein expression of CDCA genes and survival in patients with HCC using the Oncomine, UALCAN, HPA, CCLE, LinkedOmics, cBioPortal, and Metascape databases.

Results

Significant overexpression of all CDCA members was found in HCC tissues. The expression levels of CDCAs were related to the tumor stage, and high expression lev

SUBMITTER: Tao Q 

PROVIDER: S-EPMC8107601 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature