Comprehensive transcriptome analysis of colorectal cancer risk of hyperglycemia in humans.

ABSTRACT:

Background

Epidemiological studies have found that hyperglycemia, is an independent risk factor for colorectal cancer (CRC), increasing colon cancer incidence and affecting the recurrence, metastasis, and prognosis in colon cancer patients. However, the intercorrelation between hyperglycemia and CRC risk is still unknown, In the present study, we sought to determine whether gene markers, which act in CRC with hyperglycemia, are silenced in CRC without hyperglycemia.

Methods

In order to characterize the mechanism of functional genes associated with CRC with hyperglycemia, A total 24 CRC and matched controls were sequenced. Through bioinformatics analysis includes differential expression analysis, functional enrichment, new isoform prediction and alternative splicing event ide

SUBMITTER: Feng W 

PROVIDER: S-EPMC8107623 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature