SATB1 protein is associated with the epithelial‑mesenchymal transition process in non‑small cell lung cancers.

ABSTRACT: Lung cancer is one of the most frequently diagnosed neoplasms and the leading cause of cancer‑related mortality worldwide. Its predominant subtype is non‑small cell lung cancer (NSCLC), which accounts for over 80% of the cases. Surprisingly, the majority of lung cancer‑related deaths are caused not by a primary tumour itself, but by its metastasis to distant organs. Therefore, it becomes especially important to identify the factors involved in lung cancer metastatic spread. Special AT‑rich binding protein 1 (SATB1) is a nuclear matrix protein that mediates chromatin looping and plays the role of global transcriptional regulator. During the past decade, it has received much attention as a factor promoting tumour invasion. In breast, colorectal and prostate cancers, SATB1 has been shown to i

SUBMITTER: Glatzel-Plucinska N 

PROVIDER: S-EPMC8107643 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature