Systemic inflammation and protease profile of Afro-Caribbean patients with sepsis.

ABSTRACT:

Objectives

Sepsis is one of the leading causes of morbidity and mortality within the healthcare system and remains a diagnostic and therapeutic challenge. A major issue in the diagnosis of sepsis is understanding the pathophysiologic mechanism, which revolves around host immune system activation and dysregulated responses. African Americans are more likely to experience severe sepsis with higher mortality rates compared to the general population. This pilot study characterized multiple inflammatory markers and proteases in plasma of primarily African American and Afro-Caribbean patients with mild sepsis.

Methods

Plasma was collected from 16 healthy controls and 15 subjects presenting with sepsis, on admission, and again upon resolution of the signs of sepsis, defined as a re

SUBMITTER: Borhanjoo P 

PROVIDER: S-EPMC8107660 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature