Molecular Regulation of the Melatonin Biosynthesis Pathway in Unipolar and Bipolar Depression.

ABSTRACT: Melatonin is a neurohormone that maintains the circadian rhythms of the body. By regulating the secretion of other hormones and neurotransmitters, it acts as a pleiotropic modulator that affects, for example, reproductive, immune, cardiovascular, sleep, and wake systems and mood. Thus, synthetic melatonin has become an essential component in the treatment of depressive disorders. Although we know the pathway of melatonin action in the brain, we lack comprehensive cross-sectional studies on the periphery of depressed patients. This study aimed to comprehensively analyze the differences between healthy control subjects (n = 84) and unipolar and bipolar depression patients (n = 94), including an analysis of the melatonin pathway at the level of the genes and serum biomarkers. An

SUBMITTER: Dmitrzak-Weglarz M 

PROVIDER: S-EPMC8107693 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature