An overview of the published and running randomized phase 3 clinical results of radiotherapy in combination with immunotherapy.

ABSTRACT: Several studies have established that radiotherapy (RT) in combination with immunotherapy (IO) has a strong synergistic effect. RT changes the tumor microenvironment, generates local inflammation reactions, and enhances immunostimulatory effects, which are able to assist IO with improving local and systemic tumor control. In several pre-clinical reports, RT in combination with IO reveals regression of tumors locally (irradiated sites) and systemically (non-irradiated sites). Several clinical trials are currently running, mostly as phase I and II studies. This article provides an overview of the randomized, prospective reported and recruiting phase 3 clinical trials of RT in combination with IO. To date, three phase 3 trials have been published on RT and sequential IO with variable results,

SUBMITTER: Vanneste BGL 

PROVIDER: S-EPMC8107766 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature