Electrokinetic identification of ribonucleotide monophosphates (rNMPs) using thermoplastic nanochannels.

ABSTRACT: With advances in the design and fabrication of nanofluidic devices during the last decade, there have been a few reports on nucleic acid analysis using nanoscale electrophoresis. The attractive nature of nanofluidics is the unique phenomena associated with this length scale that are not observed using microchip electrophoresis. Many of these effects are surface-related and include electrostatics, surface roughness, van der Waals interactions, hydrogen bonding, and the electric double layer. The majority of reports related to nanoscale electrophoresis have utilized glass-based devices, which are not suitable for broad dissemination into the separation community because of the sophisticated, time consuming, and high-cost fabrication methods required to produce the relevant devices. In this s

SUBMITTER: Amarasekara CA 

PROVIDER: S-EPMC8107831 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature