Investigation of the association between imbalance of the intestinal flora and infantile spasms: a pilot case-control study.

ABSTRACT:

Background

The intestinal flora (IF) regulates brain function via the neuroendocrine and neuroimmune systems and influences the development of several neuropsychiatric diseases, including epilepsy. Here, we investigated the specific relationship between the IF and infantile spasms (IS), a specific form of epilepsy.

Methods

Twenty-three children suffering from IS were recruited from the Chinese PLA General Hospital. According to patient response to adrenocorticotropic hormone (ACTH) treatment, the cohort was subdivided into 2 groups: an ACTH-response group and an ACTH-no response (NR) group. A total of 21 healthy children were recruited as a control group (healthy controls: HCs) during the same time period. Fecal samples were collected from infants in the IS and HC gro

SUBMITTER: Wan L 

PROVIDER: S-EPMC8107841 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature