Estimating the glomerular filtration rate in pregnancy: The evaluation of the Nanra and CKD-EPI serum creatinine-based equations.

ABSTRACT:

Aim

To compare the performance of the Nanra and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation for estimating glomerular filtration rate in pregnancy against the 24 h urine creatinine clearance.

Methods

Pregnant women had 24 h urine collections with simultaneous serum creatinine levels. Measured 24 h urine creatinine clearance was compared to two equations: Nanra and CKD-EPI. Level of concordance was measured, with an a priori bias acceptance of ±15 ml/min/1.73 m².

Results

A total of 53 synchronous urine and serum creatinine samples were analysed. The Nanra equation had a bias of -13.4 ml/min/1.73 m² while the CKD-EPI equation had bias of 14.2 ml/min/1.73 m². Both equations showed a high degree of proportio

SUBMITTER: Gao M 

PROVIDER: S-EPMC8107967 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature