Evaluating the Association of Stillbirths After Maternal Vaccination in the Vaccine Safety Datalink.

ABSTRACT:

Objective

To evaluate whether the Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices recommended influenza and tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccinations in pregnancy are associated with increased risk of stillbirth.

Methods

We performed a case-control study in the Vaccine Safety Datalink that was matched 1:4 on site, month, and year of last menstrual period, comparing the odds of vaccination in pregnancies that ended in stillbirth (defined as fetal loss at or after 20 weeks of gestation) compared with those that ended in live birth from January 1, 2012, to September 30, 2015. We included patients with singleton pregnancies that ended in stillbirth or live birth who had at least one prenatal c

SUBMITTER: Panagiotakopoulos L 

PROVIDER: S-EPMC8108006 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature