Effectiveness and safety of dimethyl fumarate in progressive multiple sclerosis.

ABSTRACT:

Background

There is limited data analyzing the safety and effectiveness of dimethyl fumarate (DMF) in the progressive multiple sclerosis (PMS) population.

Objective

To analyze the safety and effectiveness of DMF in patients with PMS.

Methods

We used Cox proportional hazards models to compare the time to confirmed worsening and improvement on the Expanded Disability Status Scale (EDSS) and timed 25-foot walk (T25FW) between patients treated with DMF and glatiramer acetate (GA) for at least one year.

Results

We included 46 patients treated with DMF and 42 patients treated with GA. The safety and tolerability of GA and DMF were consistent with established profiles. There was no difference in confirmed EDSS progression. A trend towards reduced T25FW was seen in the

SUBMITTER: Moreira Ferreira VF 

PROVIDER: S-EPMC8108088 | biostudies-literature | 2021 Apr-Jun

REPOSITORIES: biostudies-literature