Pan-cancer analysis reveals tumor-associated macrophage communication in the tumor microenvironment.

ABSTRACT:

Background

Tumor-associated macrophages (TAMs) are abundant in the tumor microenvironment (TME). However, their contribution to the immunosuppressive status of the TME remains unclear.

Methods

We integrated single-cell sequencing and transcriptome data from different tumor types to uncover the molecular features of TAMs. In vitro experiments and prospective clinical tests confirmed the results of these analysis.

Results

We first detected intra- and inter-tumoral heterogeneities between TAM subpopulations and their functions, with CD86⁺ TAMs playing a crucial role in tumor progression. Next, we focused on the ligand-receptor interactions between TAMs and tumor cells in different TME phenotypes and discovered that aberrant expressions of six hub genes, includ

SUBMITTER: Wang L 

PROVIDER: S-EPMC8108336 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature