Bone marrow laminins influence hematopoietic stem and progenitor cell cycling and homing to the bone marrow.

ABSTRACT: Hematopoietic stem and progenitor cell (HSPC) functions are regulated by a specialized microenvironment in the bone marrow - the hematopoietic stem cell niche - of which the extracellular matrix (ECM) is an integral component. We describe here the localization of ECM molecules, in particular the laminin α4, α3 and α5 containing isoforms in the bone marrow. Laminin 421 (composed of laminin α4, β2, γ1 chains) is identified as a major component of the bone marrow ECM, occurring abundantly surrounding venous sinuses and in a specialized reticular fiber network of the intersinusoidal spaces of murine bone marrow (BM) in close association with HSPC. Bone marrow from Lama4^-/- mice is significantly less efficient in reconstituting the hematopoietic system of irradiated wildtype (WT) rec

SUBMITTER: Susek KH 

PROVIDER: S-EPMC8108389 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature