Diminished muscle oxygen uptake and fatigue in spinal muscular atrophy.

ABSTRACT:

Objective

To estimate muscle oxygen uptake and quantify fatigue during exercise in ambulatory individuals with spinal muscular atrophy (SMA) and healthy controls.

Methods

Peak aerobic capacity (VO_2peak ) and workload (W_peak ) were measured by cardiopulmonary exercise test (CPET) in 19 ambulatory SMA patients and 16 healthy controls. Submaximal exercise (SME) at 40% W_peak was performed for 10 minutes. Change in vastus lateralis deoxygenated hemoglobin, measured by near-infrared spectroscopy, determined muscle oxygen uptake (ΔHHb) at rest and during CPET and SME. Dual energy X-ray absorptiometry assessed fat-free mass (FFM%). Fatigue was determined by percent change in workload or distance in the first compared to the last minute of SME (Fatigu

SUBMITTER: Montes J 

PROVIDER: S-EPMC8108417 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature