Quantitative signal properties from standardized MRIs correlate with multiple sclerosis disability.

ABSTRACT:

Objective

To enable use of clinical magnetic resonance images (MRIs) to quantify abnormalities in normal appearing (NA) white matter (WM) and gray matter (GM) in multiple sclerosis (MS) and to determine associations with MS-related disability. Identification of these abnormalities heretofore has required specialized scans not routinely available in clinical practice.

Methods

We developed an analytic technique which normalizes image intensities based on an intensity atlas for quantification of WM and GM abnormalities in standardized MRIs obtained with clinical sequences. Gaussian mixture modeling is applied to summarize image intensity distributions from T1-weighted and 3D-FLAIR (T2-weighted) images from 5010 participants enrolled in a multinational database of MS patients wh

SUBMITTER: Brier MR 

PROVIDER: S-EPMC8108425 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature