A connectome-based approach to assess motor outcome after neonatal arterial ischemic stroke.

ABSTRACT:

Objective

Studies of motor outcome after Neonatal Arterial Ischemic Stroke (NAIS) often rely on lesion mapping using MRI. However, clinical measurements indicate that motor deficit can be different than what would solely be anticipated by the lesion extent and location. Because this may be explained by the cortical disconnections between motor areas due to necrosis following the stroke, the investigation of the motor network can help in the understanding of visual inspection and outcome discrepancy. In this study, we propose to examine the structural connectivity between motor areas in NAIS patients compared to healthy controls in order to define the cortical and subcortical connections that can reflect the motor outcome.

Methods

Thirty healthy controls and 32 NAIS patients

SUBMITTER: Al Harrach M 

PROVIDER: S-EPMC8108427 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature